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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Isoliquiritigenin, Cyclophosphamide
Phytochemical Name Isoliquiritigenin (PubChem CID: 638278 )
Anticancer drug Name Cyclophosphamide (PubChem CID: 2907 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Cyclophosphamide
Adverse Reactions Myelosuppression, body temperature increased. This was inferred hot nature anticancer drug.
Recommendations Cold: Tephrosia purpurea
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 421
Ref_1
Pair Name Isoliquiritigenin, Cyclophosphamide
Disease Info [ICD-11: 2C77.Z] Cervical cancer Investigative
Biological Phenomena Induction-->DNA damage
In Vitro Model U14 Cervical carcinoma Mus musculus (Mouse) CVCL_9U56
In Vivo Model KM mice were implanted subcutaneously with 0.2 mL (1×10⁷ mL in sodium chloride) U14 cells.
Result Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide
03. Reference
No. Title Href
1 Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. Molecules. 2013 Jul 24;18(8):8786-98. doi: 10.3390/molecules18088786. Click
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